Ingredient guide

Peptides: what it does and how to use it

Updated November 2026

Safety first: general cosmetic information, not medical advice. Patch-test new products and follow label directions. Pregnant, breastfeeding, using prescription skin treatment or managing a skin condition? Ask your doctor before trying new actives. Medical disclaimer
In short: Short chains of amino acids that act as messengers, helping skin look firmer and more resilient. Best used morning or night. Top benefit: supports firmer-looking skin.

Short chains of amino acids that act as messengers, helping skin look firmer and more resilient.

Best timeMorning or night
StrengthGentle
Good forSupports firmer-looking skin

Benefits

Who it's for

Anyone focused on firmness and early signs of aging, including sensitive skin.

How to use it

Apply as a serum or cream, morning or night, after watery layers.

Watch out for

Copper peptides are best kept apart from strong acids and pure vitamin C.

Best peptides products

Serum$$
The Ordinary Multi-Peptide + HA Serum

Peptide complex for firmer-looking, bouncier skin.

PeptidesHyaluronic acid
Check price on Amazon →
Moisturizer$$$
Drunk Elephant Protini Polypeptide Cream

Peptide-packed cream for firmer, bouncier-looking skin.

Peptides
Check price on Amazon →
Night treatment$$$
Drunk Elephant A-Passioni Retinol Cream

Vegan 1% retinol cream for visible renewal.

RetinolPeptides
Check price on Amazon →

Can you mix peptides with…

✅RetinolYes, works well⚠️Vitamin COkay, but avoid copper peptides with pure vitamin C✅NiacinamideYes, generally fine together⚠️AHAsUse at different times⚠️Salicylic acidUse at different times✅Benzoyl peroxideYes, generally fine together✅Hyaluronic acidYes, generally fine together✅Azelaic acidYes, generally fine together✅CeramidesYes, generally fine together✅SunscreenYes, generally fine together✅Tranexamic acidYes, generally fine together✅BakuchiolYes, generally fine together✅Centella (cica)Yes, generally fine together✅SqualaneYes, generally fine together

Routines that use peptides

Oily Skin: Anti-AgingDry Skin: Anti-AgingCombination Skin: Anti-AgingNormal Skin: Anti-Aging

Want a routine made for your skin?

Answer 7 quick questions and get a personalized morning and night routine. It's free and takes 60 seconds.

Take the free quiz →

FAQ

What does peptides do for skin?

Short chains of amino acids that act as messengers, helping skin look firmer and more resilient.

When should I use peptides, morning or night?

Apply as a serum or cream, morning or night, after watery layers.

Who should use peptides?

Anyone focused on firmness and early signs of aging, including sensitive skin.

This page is general cosmetic information for educational purposes. It is not medical advice, diagnosis or treatment, and it doesn't replace a dermatologist or other qualified professional. Product formulas change, so always read the label. Full medical disclaimer.